CBX6 — Chromobox 6
CBX6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CBX6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CCDC124, CISD3, DCTN2, DDA1, EIF4E2, FKBP3, GID8 +17 more | View in SCUBA |
| Fibroblasts | Rho-ROCK Contractility Cytoskeletal | ANXA6, ATP2B4, CSDE1, DYNLT3, GNG12, ITM2C, PPP1CB, ROCK1 +1 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ACAP2, ADIPOR2, ENPP4, FBXO9, GSAP, INPP4A +18 more | |
| Macrophages | Stress Response Transcription Stress | AHR, C11orf96, FAM110A, FN3K, GADD45A, LACC1, LPAR6, MKNK2 +8 more | View in SCUBA |
| Smooth muscle cells | Membrane Protein Turnover Housekeeping | ATP6AP2, AXL, BSG, CAP1, EI24, MFAP4, SSR2, TCEAL9 +1 more | View in SCUBA |
About the gene
| Chromosome | 22: 38861422-38872249 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3- independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.