Stress Response Transcription
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub GADD45A is a stress-response gene induced by DNA damage, oxidative stress, and inflammatory signals. AHR (aryl hydrocarbon receptor) is a key transcription factor in gut immune regulation and macrophage polarization. LACC1 is associated with macrophage inflammatory responses. NRARP is a Notch pathway target. MKNK2 is a stress-activated kinase. NET1 is a RhoGEF involved in cytoskeletal stress responses. The module is weakly coherent but centered on stress-response transcriptional regulation.
Genes
AHR, C11orf96, CBX6, FAM110A, FN3K, GADD45A, LACC1, LPAR6, MKNK2, NET1, NRARP, RGS12, SEMA4C, TMEM273, TSPYL2, ZBED1, ZNF503
Most correlated modules
- NF-κB Activation · correlation 0.87
- Efferocytosis Anti-inflammatory · correlation 0.82
- Resident Mac Niche · correlation 0.80
- Integrated Stress Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.