GADD45A — Growth arrest and DNA damage inducible alpha

GADD45A belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GADD45A's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response Stress	ABHD5, CEBPB, CITED2, FAM53C, GADD45B, HEXIM1, HSPA2, IER5L +9 more	View in SCUBA
CD4⁺ T cells	Regulatory T cell Immune regulation	ATP1B1, EBI3, FOXP3, GCNT1, GTF2H5, IL1R1, IL1R2, IPCEF1 +6 more	View in SCUBA
Endothelial	Notch Arterial Identity Endothelial cell development	ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 more	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	DUSP5, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1, NFKB2 +13 more
Glial cells	Anti-proliferative mRNA Decay Stress	ABHD5, BCL6, EIF4A1, FUS, MAT2A, PLK2, RBBP6, TOB1 +4 more	View in SCUBA
Goblet cells	Stress Chromatin Remodeling chromatin regulation & transcription	ETS2, KDM6B, PMAIP1, SDC4, SOX9, YBX3, ZBTB7A, ZFAND5 +1 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	AHI1, CD83, FAM107B, FKBP2, HES4, KDM6B, MRPS36, PRPF4B +7 more	View in SCUBA
Lymphatic endothelial	DNA Damage Autophagy Stress	CKS2, COQ10B, HBP1, MAP1LC3B, MSX1, NR1D1, PHLDA2, STX11 +2 more	View in SCUBA
Macrophages	Stress Response Transcription Stress	AHR, C11orf96, CBX6, FAM110A, FN3K, LACC1, LPAR6, MKNK2 +8 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1/MEF2 Activation T cell maturation	ADNP2, BHLHE40, CDK16, DBF4, ETF1, FOSL2, GPR35, GSPT1 +8 more
Natural Killer cells	EGR2/3 NK Activation activation	AMD1, CHD4, CRTAM, CSF2, DNAJB9, EGR2, EGR3, MAP2K3 +4 more	View in SCUBA
Smooth muscle cells	Secondary Response Genes Stress	ABHD2, BCL6, CSRNP1, ECM2, HRH2, LITAF, MAT2A, MCL1 +3 more	View in SCUBA

About the gene

Synonyms	DDIT1, GADD45
Chromosome	1: 67685201-67688334
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Biological process	Cell cycle, DNA damage, Growth arrest

Function

In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.