RHOBTB2 — Rho related BTB domain containing 2
RHOBTB2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHOBTB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Crypt-top colonocyte Absorption | ALDOC, AQP1, EIF4EBP2, FADS6, GRIK2, SLC17A8, SUSD2, TLCD4 | View in SCUBA |
About the gene
| Synonyms | DBC2, KIAA0717 |
|---|---|
| Chromosome | 8: 22987417-23020509 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.