Crypt-top colonocyte
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Crypt-top colonocyte program resembling the BEST4+/CA7+ or apical colonocyte state. SLC17A8, ALDOC, AQP1, SUSD2, GRIK2 and FADS6 appear in distal/crypt-top colonocyte signatures. AQP1 supports water transport and ALDOC glycolysis. Expression is lower and patchier (about 50% of cells), suggesting a sub-state.
Genes
ALDOC, AQP1, EIF4EBP2, FADS6, GRIK2, RHOBTB2, SLC17A8, SUSD2, TLCD4
Most correlated modules
- Mature enterocyte differentiation · correlation 0.92
- Brush-border Nutrient Uptake · correlation 0.91
- Chylomicron apolipoprotein assembly · correlation 0.90
- Villus-tip enterocyte transport · correlation 0.88
- Amino acid absorption · correlation 0.87
- Enterocyte lipid metabolism · correlation 0.85
- Endocytic nutrient uptake · correlation 0.85
- Brush border lipid handling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.