SUSD2 — Sushi domain containing 2
SUSD2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUSD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Crypt-top colonocyte Absorption | ALDOC, AQP1, EIF4EBP2, FADS6, GRIK2, RHOBTB2, SLC17A8, TLCD4 | View in SCUBA |
| Smooth muscle cells | Pericyte Basement Membrane ECM remodeling | ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, CSPG4, ENTPD1, HIP1 +7 more | View in SCUBA |
About the gene
| Synonyms | BK65A6.2, FLJ22778, W5C5 |
|---|---|
| Chromosome | 22: 24181487-24189106 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Receptor |
Function
May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.