AQP1 — Aquaporin 1 (Colton blood group)
AQP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AQP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Membrane Transport Endothelial cell development | CDH24, CEBPG, CLIC5, FAP, LSM6, OIT3, OSTF1, RAVER2 +9 more | View in SCUBA |
| Enterocytes | Crypt-top colonocyte Absorption | ALDOC, EIF4EBP2, FADS6, GRIK2, RHOBTB2, SLC17A8, SUSD2, TLCD4 | View in SCUBA |
| Glial cells | BMP-SMAD Signaling Neroprotection | A2M, ARC, CAPS, CRLF1, GDNF, ID1, ID3, NRXN2 +3 more | View in SCUBA |
| Goblet cells | Anti-inflammatory Lipid Signaling Housekeeping | CDCA7, FBL, IMPDH2, PRDX5, PTGDR, RARRES2, UGT2A3 | View in SCUBA |
| Pericytes | Vascular Tone Homeostasis Housekeeping | ACSL5, AQP3, ASS1, DCHS1, GIT1, NPR1, RUNDC3B, TSPAN13 +1 more | View in SCUBA |
About the gene
| Synonyms | CHIP28, CO |
|---|---|
| Chromosome | 7: 30911853-30925517 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Blood group antigen |
| Biological process | Transport |
Function
Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.