RNASE2 — Ribonuclease A family member 2
RNASE2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Promyelocyte Granule Genes Granulocyte development | AZU1, CEBPD, CFD, CTSG, ELANE, MPO, PLPPR3, PRTN3 +1 more | |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | ANG, ANXA2, CD99, IGFBP7, MGST1, PLAAT3, S100A10, ST14 | View in SCUBA |
| Neutrophils | Primary Granule Antimicrobial Degranulation | CEACAM6, DEFA3, DEFA4, DUT, HNRNPAB, MS4A3, NUCB2, RNASE3 +1 more |
About the gene
| Synonyms | EDN, RAF3, RNS2 |
|---|---|
| Chromosome | 14: 20955487-20956436 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Endonuclease, Hydrolase, Lyase, Nuclease |
| Biological process | Chemotaxis |
Function
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.