Hematopoietic progenitor cells: gene co-expression modules

Bone-marrow-derived multipotent precursors circulating at low frequency; retain self-renewal and lineage plasticity, seeding tissues to replenish myeloid and lymphoid compartments during inflammation, injury, and steady-state turnover.

SCUBA's reference network for Hematopoietic progenitor cells holds 69 gene modules covering 815 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

Cell cycle (8)

• DNA Replication S-phase · 13 genes
• Late S-phase G2 Entry · 10 genes
• Mitotic Spindle · 11 genes
• Mitotic Spindle · 10 genes
• Mitotic Spindle Checkpoint · 9 genes
• Replication Origin Licensing · 9 genes
• Replication Stress Response · 11 genes
• S-phase Progression · 10 genes

Cytoskeletal (1)

• Cytoskeletal Remodeling · 14 genes

Erythropoietic (7)

• Erythro-Megakaryocytic Development · 10 genes
• Erythroid Differentiation · 14 genes
• Erythroid Glycolysis · 12 genes
• Erythroid Heme Synthesis · 11 genes
• Erythroid Maturation Signaling · 12 genes
• Erythroid Progenitor Program · 12 genes
• Mature Erythrocyte · 13 genes

Granulocyte development (6)

• Eosinophil Differentiation · 8 genes
• Granulocyte Commitment · 15 genes
• Mast Cell Basophil · 10 genes
• Mast Cell Differentiation · 15 genes
• Mast Cell Progenitor · 11 genes
• Promyelocyte Granule Genes · 10 genes

Housekeeping (9)

• Biosynthetic Housekeeping · 16 genes
• Chaperonin TRiC Complex · 13 genes
• DNA Damage Repair · 8 genes
• ER Protein Folding · 22 genes
• General Metabolic Housekeeping · 8 genes
• Metabolic Housekeeping · 9 genes
• Nucleotide Metabolism · 11 genes
• Ribosome Biogenesis · 11 genes
• RNA Processing Housekeeping · 17 genes

Inflammatory (4)

• Cytokine Feedback Signaling · 11 genes
• Glucocorticoid Response · 13 genes
• Interferon Stimulated · 8 genes
• Megakaryocyte IFN-primed · 11 genes

Lymphcyte development (12)

• ILC/NK Development · 16 genes
• ILC2-like State · 9 genes
• ILC3/γδT Priming · 17 genes
• Lymphocyte Signaling · 12 genes
• Lymphoid Progenitor Commitment · 12 genes
• Lymphoid Progenitor TFs · 13 genes
• Lymphoid-Primed Progenitor · 13 genes
• Naive B Cell · 13 genes
• Pro-B Progenitor · 13 genes
• Regulatory T-cell State · 18 genes
• T-cell Progenitor · 11 genes
• T/NK Cell Identity · 12 genes

Mitochondrial & OxPhos (1)

• Proteostasis & OxPhos · 9 genes

Myeloid development (9)

• Dendritic Cell Progenitor · 10 genes
• Early Myeloid Progenitor · 8 genes
• Megakaryocyte Commitment · 10 genes
• MHC-I Antigen Presentation · 19 genes
• MHC-II Antigen Presentation · 10 genes
• Myeloid Commitment · 13 genes
• Myeloid Innate Immune · 14 genes
• Myeloid Lipid Signaling · 8 genes
• Platelet Biogenesis · 15 genes

Stemness (11)

• Chromatin Remodeling · 13 genes
• Hematopoietic Progenitor Identity · 11 genes
• HOX HSC Program · 12 genes
• HPC Stemness Program · 12 genes
• HSC Progenitor Proliferation · 9 genes
• HSC Quiescence Program · 16 genes
• HSC Stem Identity · 9 genes
• HSC Stemness Program · 13 genes
• Multipotent Progenitor Identity · 11 genes
• Multipotent Progenitor State · 9 genes
• Quiescent HSC State · 9 genes

Stress (1)

• Oxidative Stress Survival · 8 genes