CEBPD — CCAAT enhancer binding protein delta

CEBPD belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CEBPD's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Th17/MAIT type-17 Th17 fate	AKT1S1, CA10, CA2, CCL20, GFPT2, IL22, IL4I1, LRRN3 +9 more	View in SCUBA
Endothelial	Endothelial Chemokine Response Chemotaxis	BMP2, CCL2, CEBPB, CNKSR3, CXCL1, CXCL2, CXCL3, CXCL8 +14 more	View in SCUBA
Fibroblasts	Inflammatory TF Response Inflammatory	ADAMTS4, CMIP, FOSL2, KLF9, MAT2A, NR4A1, NR4A2, NR4A3 +2 more	View in SCUBA
Gamma-delta T cells	γδT17 Effector Inflammation	AQP3, CCR6, COLQ, CTSA, CTSH, EDEM2, GCHFR, IL23R +10 more
Glial cells	Inflammatory Activation Response Inflammation	ANGPTL4, C11orf96, CD83, ENY2, GEM, IDI1, IRF9, LMO4 +3 more	View in SCUBA
Goblet cells	Nucleotide Metabolism Stress Stress	APRT, CYB5A, LY6E, NFKBIZ, NME3, PNKD, TYMP	View in SCUBA
Hematopoietic progenitor cells	Promyelocyte Granule Genes Granulocyte development	AZU1, CFD, CTSG, ELANE, MPO, PLPPR3, PRTN3, RNASE2 +1 more
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CITED2, DENND3, EIF4B +31 more	View in SCUBA
Natural Killer cells	Inflammatory Stress Response Stress	AKIRIN2, CCNH, CLASP1, FKBP5, H3C1, P2RX5, PARP8, PIK3IP1 +2 more	View in SCUBA
Neutrophils	Neutrophil Chemotaxis Receptors Chemotaxis	CXCR1, CXCR2, EVI2B, FCGR3A, FCGR3B, NRBF2, WAS, YPEL3
Pericytes	Cytokine Inflammatory Response Inflammatory	ADAMTS4, C11orf96, CEBPB, GEM, ID4, KCNE4, PHLDA1, RGS16 +4 more	View in SCUBA
Smooth muscle cells	Glucocorticoid Metallothionein Response Stress	CEBPB, FKBP5, MT1E, MT1M, MT1X, MT2A, PNRC1, TSC22D1 +3 more	View in SCUBA

About the gene

Synonyms	C/EBP-delta, CELF, CRP3, NF-IL6-beta
Chromosome	8: 47736913-47738164
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.