RNASE3 — Ribonuclease A family member 3
RNASE3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASE3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Promyelocyte Granule Genes Granulocyte development | AZU1, CEBPD, CFD, CTSG, ELANE, MPO, PLPPR3, PRTN3 +1 more | |
| Neutrophils | Primary Granule Antimicrobial Degranulation | CEACAM6, DEFA3, DEFA4, DUT, HNRNPAB, MS4A3, NUCB2, RNASE2 +1 more |
About the gene
| Synonyms | ECP, RAF1, RNS3 |
|---|---|
| Chromosome | 14: 20891385-20892348 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease |
Function
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.