SCYL1 — SCY1 like pseudokinase 1
SCYL1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCYL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Ubiquitin-Proteasome System Protein processing & ER | ADRM1, ARL2BP, ARPP19, C1orf122, CCNC, CHMP4C, FAM118B, FBXL6 +11 more | View in SCUBA |
About the gene
| Synonyms | GKLP, HT019, MGC78454, NKTL, NTKL, P105, TAPK, TEIF, TRAP |
|---|---|
| Chromosome | 11: 65525077-65538704 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding |
| Biological process | ER-Golgi transport, Transcription, Transcription regulation, Transport |
Function
Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.