CCNC — Cyclin C
CCNC belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCNC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Oxidative Phosphorylation Mitochondrial & OxPhos | APEX1, ATP5F1A, COA3, DMAC1, ESD, HDAC2, HINT2, LAMTOR1 +15 more | View in SCUBA |
About the gene
| Synonyms | CycC |
|---|---|
| Chromosome | 6: 99542387-99568825 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, Cyclin, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.