Ubiquitin-Proteasome System
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes UBQLN1 (ubiquilin-1, proteasome shuttle factor), UFD1 (ubiquitin fusion degradation 1), and ADRM1 (proteasome 19S regulatory subunit receptor) anchor this module firmly in the ubiquitin-proteasome system (UPS). CHMP4C (ESCRT-III subunit) and CCNC (cyclin C, CDK8 mediator complex) add proteasome-linked degradation and transcriptional regulation. FBXL6 (F-box protein, SCF E3 ligase) and SCYL1 (kinase involved in protein quality control) further support UPS activity. ARPP19 regulates phosphatase PP2A, which controls proteasome substrate phosphorylation. The module is uniformly expressed, strongly coherent, and lacks disease-specific enrichment, consistent with a constitutive protein quality control program in colonocytes.
Genes
Most correlated modules
- Vesicular Trafficking · correlation 0.90
- ER Stress & UPR · correlation 0.87
- Ribosome Biogenesis · correlation 0.86
- Mitochondrial Maintenance · correlation 0.84
- Cellular Senescence · correlation 0.83
- Stem Cell Epigenetic · correlation 0.81
- Inflammatory Cytoskeletal Remodeling · correlation 0.78
- ER Stress & Trafficking · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.