SLC2A8 — Solute carrier family 2 member 8
SLC2A8 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC2A8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36 +15 more | View in SCUBA |
About the gene
| Synonyms | GLUT8, GLUTX1 |
|---|---|
| Chromosome | 9: 127397138-127408424 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Sugar transport, Transport |
Function
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.