SPINDOC — Spindlin interactor and repressor of chromatin binding
SPINDOC belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPINDOC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | G1/S Entry Cell cycle | CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more |
About the gene
| Synonyms | C11orf84, SPIN-DOC |
|---|---|
| Chromosome | 11: 63813456-63827716 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | DNA damage, Transcription, Transcription regulation |
Function
Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3). Positively regulates poly-ADP- ribosylation in response to DNA damage; acts by facilitating PARP1 ADP- ribosyltransferase activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.