SPOCD1 — SPOC domain containing 1
SPOCD1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPOCD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | TGF-beta Fibroblast Niche ECM production | APCDD1, BAG2, C12orf75, CD55, CES1, CGREF1, COL11A1, CRYAB +8 more | View in SCUBA |
About the gene
| Synonyms | FLJ25348, PPP1R146 |
|---|---|
| Chromosome | 1: 31790422-31816022 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Differentiation, RNA-mediated gene silencing, Spermatogenesis |
Function
Protein adapter that acts as an essential executor of PIWIL4- piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (By similarity). Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation. Not required for piRNA biosynthesis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.