CRYAB — Crystallin alpha B
CRYAB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CRYAB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | TGF-beta Fibroblast Niche ECM production | APCDD1, BAG2, C12orf75, CD55, CES1, CGREF1, COL11A1, IRS1 +8 more | View in SCUBA |
| Pericytes | Myosin Phosphatase Regulation Cytoskeletal | CALM2, CRIP1, HCFC1R1, JAG1, LBH, MAP3K7CL, PHLDA2, PLAC9 +2 more | View in SCUBA |
| Smooth muscle cells | Ribonucleoprotein & translation RNA processing & translation | CYB5R3, EEF1B2, HMGB1, HNRNPC, LAPTM4A, MAGED2, NACA, NCL +5 more | View in SCUBA |
About the gene
| Synonyms | CRYA2, HSPB5 |
|---|---|
| Chromosome | 11: 111908564-111923722 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Chaperone, Eye lens protein |
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.