TGF-beta Fibroblast Niche
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub gene TGFBR3 (TGF-beta receptor III/betaglycan, co-receptor modulating TGF-beta and BMP signaling), MFAP5 (microfibril-associated glycoprotein 5, ECM/elastic fiber), APCDD1 (Wnt inhibitor, fibroblast identity marker), LRRC17 (leucine-rich repeat, fibroblast subtype marker), PRDM6 (PR domain zinc finger, smooth muscle transcription factor), CRYAB (alpha-B crystallin, stress chaperone/myofibroblast), COL11A1 (collagen XI, ECM), CD55 (complement decay-accelerating factor), IRS1 (insulin receptor substrate), BAG2 (chaperone co-regulator), UTRN (utrophin, cytoskeletal). This module reflects a specific fibroblast subpopulation identity defined by TGF-beta/BMP co-receptor expression and ECM/elastic fiber genes, consistent with a sublaminal/adventitial fibroblast niche. Upregulated in UC inflammation.
Genes
APCDD1, BAG2, C12orf75, CD55, CES1, CGREF1, COL11A1, CRYAB, IRS1, LRRC17, MFAP5, PRDM6, RAB23, SPOCD1, TGFBR3, UTRN, VSTM2L
Most correlated modules
- Notch Fibroblast Activation · correlation 0.86
- Stromal Niche Identity · correlation 0.82
- Myofibroblast Contractile · correlation 0.79
- Caveolae Mechanosensing · correlation 0.78
- ECM Homeostasis · correlation 0.78
- Smooth Muscle Identity · correlation 0.76
- Wnt-Niche Fibroblast · correlation 0.72
- BMP-Wnt Niche Signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.