APCDD1 — APC down-regulated 1
APCDD1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APCDD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | CREB3L2, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1, LGMN +11 more | View in SCUBA |
| Fibroblasts | TGF-beta Fibroblast Niche ECM production | BAG2, C12orf75, CD55, CES1, CGREF1, COL11A1, CRYAB, IRS1 +8 more | View in SCUBA |
| Glial cells | Neuroprotective Secretory Neroprotection | ANGPTL7, IGFBP6, LRRTM1, PDLIM2, PRELP, SELENOP, TTR, TXNIP +1 more | View in SCUBA |
| Smooth muscle cells | FOXF2 Mesenchymal Patterning Development | ADAMTS6, BDKRB2, DCHS1, FAT4, FOXF2, KCNH2, MFAP5, P2RY14 +2 more | View in SCUBA |
About the gene
| Synonyms | B7323 |
|---|---|
| Chromosome | 18: 10454635-10489949 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Wnt signaling pathway |
Function
Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.