STAT5B — Signal transducer and activator of transcription 5B
STAT5B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STAT5B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | JAK-STAT Signaling Immune regulation | ARHGAP30, CELF2, DDX17, DNAJC1, GSDMD, HCLS1, JAK3, MBNL1 +7 more | View in SCUBA |
| Gamma-delta T cells | TCR-Cytokine Signaling TCR Signaling | ARHGAP26, CACNA2D2, CCDC88C, LPGAT1, LY75, MED15, NBPF14, NBPF19 +10 more | |
| Neutrophils | Granulopoiesis Transcriptional Developmental | EXT1, KLHL2, MAML3, PDE3B, PHF21A, SIPA1L2, TPST1 |
About the gene
| Chromosome | 17: 42199176-42288633 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.