SULT1C4 — Sulfotransferase family 1C member 4
SULT1C4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SULT1C4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | CNTNAP3B, CYB5RL, FOXO1, IL7, ITSN1, KIF3C, KRT8, LRCH2 +6 more | View in SCUBA |
About the gene
| Synonyms | SULT1C, SULT1C2 |
|---|---|
| Chromosome | 2: 108377911-108388989 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.