TBXAS1 — Thromboxane A synthase 1
TBXAS1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TBXAS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 effector Th17 fate | CD6, CLSTN3, CTDSP1, IL17A, ITPRIPL2, MAP3K4, MPRIP, NFIL3 +6 more | View in SCUBA |
| Monocytes | Monocyte Identity Innate immunity | C1orf162, CD68, CDK2AP1, CMTM7, DBNDD2, EIF4EBP3, MIF, NME2 | View in SCUBA |
| Neutrophils | Endosomal Vesicle Trafficking Vesicular traficking | DIP2B, ELF2, JAK1, NRDC, OSBPL8, PCNX1, PICALM, SLC12A6 +3 more |
About the gene
| Synonyms | CYP5, CYP5A1, THAS, TS, TXAS, TXS |
|---|---|
| Chromosome | 7: 139777051-140020325 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Isomerase, Lyase, Monooxygenase, Oxidoreductase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism |
Function
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12- HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.