TJP2 — Tight junction protein 2
TJP2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TJP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLIC2 +22 more | View in SCUBA |
About the gene
| Synonyms | DFNA51, X104, ZO-2, ZO2 |
|---|---|
| Chromosome | 9: 69121264-69274615 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.