TMEM126A — Transmembrane protein 126A
TMEM126A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM126A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | ATP Synthase Complex Mitochondrial & OxPhos | ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, GTF3C6, LSM6 +14 more | View in SCUBA |
About the gene
| Synonyms | DKFZp586C1924, OPA7 |
|---|---|
| Chromosome | 11: 85647967-85656547 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
Function
Protein required for the cotranslational protein quality control in the inner membrane of the mitochondria. Associates with newly synthesized polypeptides and may act as a chaperone that cooperates with OXA1L for the insertion of newly synthesized mitochondrial proteins into the inner membrane. Required for the assembly of the ND4 module of mitochondrial complex I.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.