GTF3C6 — General transcription factor IIIC subunit 6
GTF3C6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTF3C6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA processing splicing RNA processing | BUD31, DNAJC8, EDF1, EIF2S1, HPRT1, ILF2, LAMTOR5, MIIP +11 more | View in SCUBA |
| CD8⁺ T cells | Complex I / OXPHOS Mitochondrial & OxPhos | DAD1, GSTO1, MANF, NDUFA12, NDUFA4, NDUFAB1, NDUFB3, NDUFS6 +1 more | View in SCUBA |
| Fibroblasts | ER Protein Processing Vesicular traficking | ARPC2, ENO1, KDELR2, LMAN1, OSTC, P4HB, PRDX4, PSMC4 +5 more | View in SCUBA |
| Innate lymphoid cells | Proteasome ER Proteostasis Protein processing & ER | ATP5MC1, ATP5PF, DBI, GNG5, HNRNPK, IL4I1, MANF, MED10 +19 more | View in SCUBA |
| Macrophages | ATP Synthase Complex Mitochondrial & OxPhos | ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, LSM6, MGST3 +14 more | View in SCUBA |
About the gene
| Synonyms | bA397G5.3, C6orf51, TFIIIC35 |
|---|---|
| Chromosome | 6: 110958706-110967890 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription |
Function
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.