GTF2A2 — General transcription factor IIA subunit 2
GTF2A2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTF2A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ER Calcium Stress Stress | ACOT7, ATP2A2, CALU, ELOVL5, LYAR, PSMD7, RCC2, UFD1 +1 more | View in SCUBA |
| Goblet cells | Basal Transcription Housekeeping | ACTB, ACTG1, CALM2, DYNLL1, ELOC, ENY2, LSM8, POLR2K +2 more | View in SCUBA |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3 +26 more | View in SCUBA |
| Macrophages | ATP Synthase Complex Mitochondrial & OxPhos | ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF3C6, LSM6, MGST3 +14 more | View in SCUBA |
About the gene
| Synonyms | HsT18745, TFIIA |
|---|---|
| Chromosome | 15: 59638062-59657541 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.