ATP Synthase Complex
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 23 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes are predominantly mitochondrial ETC subunits: NDUFB3 (Complex I), ATP5MJ/ATP5MK/ATP5PF (ATP synthase subunits c/k/f), COX7A2/COX7B (Complex IV), NDUFAB1 (Complex I acyl carrier protein), TMEM126A (Complex I assembly factor). Mitoribosome: MRPL15, MRPL52, MRPL22, MRPS23. Mitochondrial RNA/DNA: SSBP1 (mtDNA binding), SLIRP (mitochondrial RNA binding). Peripheral genes: GTF3C6, RBX1, TXNDC17, POMP, THOC7, MGST3. The module is tightly centered on ATP synthase and Complex I/IV subunits.
Genes
ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, GTF3C6, LSM6, MGST3, MRPL15, MRPL22, MRPL52, MRPS23, NDUFAB1, NDUFB3, POMP, RBX1, SF3B6, SLIRP, SSBP1, THOC7, TMEM126A, TXNDC17
Most correlated modules
- Spliceosomal snRNP · correlation 0.97
- Protein Homeostasis Mixed · correlation 0.96
- Proteasome UPS · correlation 0.95
- Mitochondrial Biogenesis · correlation 0.95
- Oxidative Phosphorylation · correlation 0.95
- Glycolytic Metabolism · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.94
- Proteasome UPS · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.