LSM6 — LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
LSM6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LSM6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Membrane Transport Endothelial cell development | AQP1, CDH24, CEBPG, CLIC5, FAP, OIT3, OSTF1, RAVER2 +9 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Housekeeping Mitochondrial & OxPhos | ARL2, BRAT1, C11orf58, CCDC115, CD3E, CHMP4A, CHURC1, DPM3 +13 more | |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ERCC1, ETFB, GLRX3 +12 more | View in SCUBA |
| Macrophages | ATP Synthase Complex Mitochondrial & OxPhos | ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, GTF3C6, MGST3 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Homeostasis Housekeeping | ATP5PB, COPZ1, FERMT3, GPS1, HMGN4, ICAM2, LAMTOR2, LCK +14 more |
About the gene
| Synonyms | YDR378C |
|---|---|
| Chromosome | 4: 146175703-146200000 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | mRNA processing, mRNA splicing, rRNA processing, tRNA processing |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.