TMEM129 — Transmembrane protein 129, E3 ubiquitin ligase
TMEM129 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM129's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mitochondrial Biogenesis Mitochondrial & OxPhos | BCAT2, BCS1L, CCND2, CEP70, CLUH, CRLS1, CRTAP, DNAJA3 +28 more | View in SCUBA |
About the gene
| Synonyms | D4S2561E |
|---|---|
| Chromosome | 4: 1715952-1721358 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway, Unfolded protein response |
Function
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.