CCND2 — Cyclin D2

CCND2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CCND2's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Cytotoxic Gut Effector cytotoxicity	ATP8B4, CD63, CEBPB, CSF1, CTSA, GNLY, GNPTAB, GZMA +3 more	View in SCUBA
Enterocytes	Transit-amplifying progenitor Epithelial development	CLINT1, EHF, ELOVL6, HSD17B12, MSI2, PKP2, RBM3, SLC38A1	View in SCUBA
Goblet cells	BMP Signaling Response Epithelial development	CAMK2N1, EIF4A2, GSTA1, GSTA4, ID2, ID3, PDK4, ZBTB10	View in SCUBA
Innate lymphoid cells	Cell Cycle Entry Cell cycle	EIF1B, ENY2, KMT2E, LUZP1, RAB8A, TPM4	View in SCUBA
Mucosal-associated invariant T cell	Chromatin Complex Regulation DNA/chromatin regulation	APEH, CAPZB, CFH, CHTF8, ESYT1, GDI2, HACD4, HCLS1 +9 more

About the gene

Chromosome	12: 4269771-4305353
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Molecular function	Cyclin
Biological process	Cell cycle, Cell division

Function

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.