Mitochondrial Biogenesis
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 37 genes have a known function matching the annotation |
Why this annotation
Key hub genes include LRPPRC (mitochondrial RNA processing/stability), CLUH (mRNA clustering for mitochondrial protein import), MRPL12 (mitochondrial large ribosomal subunit), DNAJA3 (mitochondrial DnaJ chaperone), SFXN4 (mitochondrial sideroflexin, iron transport), PTCD3 (mitochondrial ribosome assembly factor), IVD (isovaleryl-CoA dehydrogenase, mitochondrial leucine catabolism), QTRT1 (mitochondrial tRNA queuosine modification). Additional genes MYB and PPP1R1B reflect crypt progenitor transcriptional identity. As a neighbor to M103, this module extends the mitochondrial biogenesis program with emphasis on mitochondrial RNA processing and import. Suppressed in inflammation, restored in UC remission.
Genes
Most correlated modules
- DNA Repair Housekeeping · correlation 0.96
- Mitochondrial Translation · correlation 0.94
- SWI-SNF DNA Repair · correlation 0.91
- Ribosome Biogenesis · correlation 0.91
- BMP-ID Progenitor · correlation 0.90
- snRNP Splicing · correlation 0.88
- Chaperone Proteostasis · correlation 0.88
- eIF3 Translation Initiation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.