TPRN — Taperin
TPRN belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TPRN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Colonocyte Cytoskeletal Contractility Cytoskeletal | ACTN4, AOC1, ARHGAP17, ASAP2, CDHR5, CLCN2, CTSD, DGKA +27 more | View in SCUBA |
About the gene
| Synonyms | C9orf75, DFNB79, FLJ90254 |
|---|---|
| Chromosome | 9: 137191617-137204193 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding, Protein phosphatase inhibitor |
| Biological process | Hearing |
Function
Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity. Recruited to sites of DNA damage and may play a role in DNA damage repair.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.