ASAP2 — ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASAP2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenic Activation Inflammation | ALPL, APOL4, CALM1, COMMD2, FAT4, PDGFB, PLS3, RALGAPA1 +4 more | View in SCUBA |
| Smooth muscle cells | Calcium Handling Contractility | DDX24, MYCBP2, NBDY, PDE1A, RBM24, RNF180, RRAS, RYR2 +3 more | View in SCUBA |
About the gene
| Synonyms | CENTB3, DDEF2, KIAA0400, PAP, SHAG1 |
|---|---|
| Chromosome | 2: 9206765-9405683 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.