AOC1 — Amine oxidase copper containing 1
AOC1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AOC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature enterocyte differentiation Absorption | ABCC2, ACSF2, CDC14A, CEP350, EEPD1, EPS8L2, GRAMD1C, MXI1 +5 more | View in SCUBA |
About the gene
| Synonyms | ABP, ABP1, DAO |
|---|---|
| Chromosome | 7: 150824627-150861504 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted secreted proteins |
| Molecular function | Heparin-binding, Oxidoreductase |
Function
Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.