Colonocyte Cytoskeletal Contractility
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 36 genes have a known function matching the annotation |
Why this annotation
MAPK3 (ERK1, proliferation/differentiation signaling), ACTN4 (alpha-actinin-4, actin crosslinker), MYH14/MYH9 (non-muscle myosin heavy chains, cytoskeletal contractility), GPA33 (A33 antigen, colon-specific surface glycoprotein), SCNN1A (epithelial sodium channel alpha, ion transport), CDHR5 (protocadherin, brush border), FLNB (filamin B, actin-binding), PTK6 (BRK, epithelial tyrosine kinase), NFE2L1 (NRF1, oxidative stress transcription factor), SIRT7 (sirtuin-7, chromatin regulation), DGKA (diacylglycerol kinase alpha). The module combines cytoskeletal contractility (myosin, actinin, filamin) with colonocyte-specific surface markers (GPA33, CDHR5, SCNN1A) and signaling kinases. Moderate sen_colono enrichment with broader uniform expression suggests a late-differentiated/surface colonocyte cytoskeletal program.
Genes
Most correlated modules
- ESCRT Membrane Remodeling · correlation 0.96
- Senescent Cell Death · correlation 0.92
- Senescent Surface Identity · correlation 0.90
- Senescent Stress Signaling · correlation 0.89
- Membrane Cytoskeletal Remodeling · correlation 0.89
- Lysosomal Lipid Stress · correlation 0.88
- Lipid Metabolism · correlation 0.87
- Mature Colonocyte Identity · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.