TTYH1 — Tweety family member 1
TTYH1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TTYH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Mature Glial Identity Neroprotection | BMP7, CHADL, CNTN1, MT3, PPP1R1B, PPP2R2B, SFRP5, UCHL1 +1 more | View in SCUBA |
About the gene
| Chromosome | 19: 54415219-54436904 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Chloride channel, Ion channel |
| Biological process | Cell adhesion, Ion transport, Transport |
Function
Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. Ca(2+)-independent, swelling-activated chloride channel, possibly involved in regulation of cell volume
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.