Mature Glial Identity
Gene co-expression module in Glial cells
| Category | Neroprotection |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Core coherence module with very low baseline expression (7.9% positive) that dramatically decreases in both UC and CD inflammation and strongly recovers in remission. MT3 (metallothionein-3) is a brain/glial-specific metallothionein neuroprotective against oxidative stress. TTYH1 is a tweety homolog chloride channel highly specific to astrocytes and enteric glia. UCHL1 is a canonical neuronal/glial marker. CNTN1 (contactin-1) mediates glial-axon interactions. BMP7 and WNT6/SFRP5 constitute a morphogenetic signaling axis. PPP2R2B and PPP1R1B (DARPP-32) indicate mature neuronal/glial signaling. This module represents a mature, quiescent enteric glial identity program with neuroprotective and morphogenetic components lost during inflammation.
Genes
BMP7, CHADL, CNTN1, MT3, PPP1R1B, PPP2R2B, SFRP5, TTYH1, UCHL1, WNT6
Most correlated modules
- Enteric Glial Identity · correlation 0.77
- Enteric Glial Homeostasis · correlation 0.77
- Peripheral Nerve Myelination · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.