SFRP5 — Secreted frizzled related protein 5
SFRP5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SFRP5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Adventitial Fibroblast State Developmental | AKAP7, BLNK, C1QA, CACNA1G, CALCRL, COL21A1, CYP1B1, FAT3 +9 more | View in SCUBA |
| Glial cells | Mature Glial Identity Neroprotection | BMP7, CHADL, CNTN1, MT3, PPP1R1B, PPP2R2B, TTYH1, UCHL1 +1 more | View in SCUBA |
About the gene
| Synonyms | SARP3 |
|---|---|
| Chromosome | 10: 97766751-97771999 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Wnt signaling pathway |
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.