PPP2R2B — Protein phosphatase 2 regulatory subunit Bbeta
PPP2R2B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP2R2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory effector Immune regulation | C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EIF4E3, EPB41, FYCO1 +9 more | View in SCUBA |
| Glial cells | Mature Glial Identity Neroprotection | BMP7, CHADL, CNTN1, MT3, PPP1R1B, SFRP5, TTYH1, UCHL1 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcineurin-NFAT Signaling TCR Signaling | AKT3, CDC14A, IQGAP2, NCALD, NEK7, PLCB1, PLCL2, PPP3CA +3 more | |
| Smooth muscle cells | Adrenergic Neuronal Transcripts Contractility | ADRA2B, BCAS4, CCDC153, CLYBL, FBXL13, LSMEM2, PTPN3, RIMS3 +2 more | View in SCUBA |
About the gene
| Synonyms | B55beta, PR52B, PR55-BETA, SCA12 |
|---|---|
| Chromosome | 5: 146580742-147084784 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.