UNC5D — Unc-5 netrin receptor D
UNC5D belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UNC5D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Stromal Niche Signaling Developmental | ARHGAP20, COL15A1, CPNE8, IL7, ITIH5, KCNS3, KITLG, LIFR +7 more | View in SCUBA |
About the gene
| Synonyms | KIAA1777, Unc5h4 |
|---|---|
| Chromosome | 8: 35235475-35796550 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Receptor |
| Biological process | Apoptosis |
Function
Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.