COL15A1 — Collagen type XV alpha 1 chain
COL15A1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL15A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Basement Membrane Assembly ECM remodeling | COL4A1, COL4A2, HSPG2, KIFC3, MGAT4A, NDST1, NOL4L, ORAI2 +4 more | View in SCUBA |
| Fibroblasts | Stromal Niche Signaling Developmental | ARHGAP20, CPNE8, IL7, ITIH5, KCNS3, KITLG, LIFR, PCDH19 +7 more | View in SCUBA |
| Glial cells | Collagen ECM Deposition ECM remodeling | COL18A1, COL1A1, COL28A1, COL4A1, COL4A2, COL5A2, COL6A2, FLNA +2 more | View in SCUBA |
| Pericytes | YAP/TAZ Mechanosensing Developmental | CARHSP1, ENG, MLEC, NOL4L, TMEM204, TRIOBP, VAT1, WWTR1 +1 more | View in SCUBA |
| Smooth muscle cells | ER-Golgi Secretory Pathway Protein processing & ER | BZW1, CCT3, GPC6, IFT57, KDELR2, LRPAP1, NFATC4, PAM +4 more | View in SCUBA |
About the gene
| Chromosome | 9: 98943179-99070792 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Angiogenesis, Cell adhesion, Differentiation |
Function
Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Restin potently inhibits angiogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.