KITLG — KIT ligand
KITLG belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KITLG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-kB Chromatin Regulation DNA/chromatin regulation | ARHGEF3, DGKE, HLA-E, HOXB3, IKBKB, ITPKB, LIMCH1, MALT1 +4 more | View in SCUBA |
| Fibroblasts | Stromal Niche Signaling Developmental | ARHGAP20, COL15A1, CPNE8, IL7, ITIH5, KCNS3, LIFR, PCDH19 +7 more | View in SCUBA |
About the gene
| Synonyms | DFNA69, FPH2, Kitl, KL-1, MGF, SCF, SF, SLF |
|---|---|
| Chromosome | 12: 88492793-88580851 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins |
| Molecular function | Growth factor |
| Biological process | Cell adhesion |
Function
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.