LIFR — LIF receptor subunit alpha
LIFR belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIFR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Barrier Homeostasis migration & adhesion | AFDN, CD2AP, CLEC3B, ENPP2, IFNGR1, IL6R, ITGB4, JAM2 +11 more | View in SCUBA |
| Fibroblasts | Stromal Niche Signaling Developmental | ARHGAP20, COL15A1, CPNE8, IL7, ITIH5, KCNS3, KITLG, PCDH19 +7 more | View in SCUBA |
| Lymphatic endothelial | IL33 Alarmin Response Inflammation | CLIC4, EPAS1, HRCT1, IGFBP5, IL33, PLAT, PLSCR1, PRELP +4 more | View in SCUBA |
About the gene
| Synonyms | CD118 |
|---|---|
| Chromosome | 5: 38474668-38608354 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.