Oxidative Phosphorylation
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 28 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by mitochondrial electron transport chain and oxidative phosphorylation components: NDUFB3, NDUFB8, NDUFB4, NDUFS6 (Complex I), ATP5F1C, ATP5PF (ATP synthase), COX6B1 (Complex IV), MDH2/OGDH-type TCA, PGAM1 (glycolysis), FIS1/PRELID1 (mitochondrial). This is a coherent OxPhos/metabolic module. Uniform expression, no contamination signal. Positively associated with inflammation, consistent with metabolic activation of effector T cells.
Genes
AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS, FIS1, MDH2, MIEN1, NDUFA3, NDUFB3, NDUFB4, NDUFB8, NDUFS6, PGAM1, PPP4C, PRELID1, PSMD13, SPCS1, TBCB, THOC7, TMCO1, TMEM160, UBE2N, UQCRQ, ZNHIT1
Most correlated modules
- Oxidative Phosphorylation · correlation 0.87
- Oxidative phosphorylation · correlation 0.87
- Effector Immune Activation · correlation 0.86
- Cytoskeleton & metabolism · correlation 0.84
- OxPhos & redox · correlation 0.83
- Interferon-stimulated genes · correlation 0.83
- Mitochondrial OxPhos · correlation 0.82
- RNA & Chromatin Regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.