Cytotoxic effector
Gene co-expression module in CD4⁺ T cells
| Category | Cytotoxicity |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes S100A10, S100A11, VIM, EMP3, IFITM2, EMP3, PLP2, KLRG1, CTSW, TGFB1, SOD2 define an effector/cytotoxic-like, migratory CD4 T cell state. S100A10/S100A11/VIM/EMP3 are associated with effector/migratory phenotypes; KLRG1 and CTSW mark terminally differentiated/cytotoxic cells; IFITM2 and SOD2 reflect activation/oxidative stress. This is an effector/effector-memory cytotoxic CD4 program. Positive in inflammation (CD), consistent with effector activation.
Genes
ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR, PLP2, PPP1R14B, PTGDR, RASSF3, RTL5, S100A10, S100A11, SLCO3A1, SOD2, STK38, TGFB1, VIM
Most correlated modules
- Resting memory T cell · correlation 0.85
- TCR signaling · correlation 0.72
- Ribosomal proteins · correlation 0.69
- Cytokine signaling · correlation 0.69
- Unfolded Protein Response · correlation 0.64
- Cytotoxic Effector CD4 · correlation 0.63
- T cell quiescence · correlation 0.61
- Immediate Early AP-1 · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.