Chemokine Migration
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Contains RGS1, GNG2, CCR6, CYTIP, SYTL3, FRMD4B - chemokine/GPCR signaling and migration/adhesion genes. CCR6 is the canonical Th17/gut homing receptor, RGS1 modulates chemokine receptor signaling and gut T-cell retention, GNG2 is a G-protein subunit, CYTIP regulates integrin adhesion. RUNX3 is a tissue-resident/effector T-cell transcription factor. PHLDA1, RGS1, PDE4B reflect activation. Combined with CCR6 the program points to gut-homing/migratory effector CD4 T cells. The modest inflammation association supports a tissue-resident migratory state.
Genes
CCR6, CYTIP, DDX24, FRMD4B, G3BP2, GNG2, GPBP1, KMT2E, PDE4B, PHLDA1, RGS1, RUNX3, SAMSN1, SYTL3, TANK, TENT5C
Most correlated modules
- TCR Activation Signaling · correlation 0.78
- Interferon Response · correlation 0.77
- Inflammatory effector · correlation 0.65
- TNF/NF-kB activation · correlation 0.64
- Effector activation NFkB · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.