Glucocorticoid Immunoregulation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub TSC22D3 (GILZ, glucocorticoid-induced immunoregulator), TSPYL2, WSB1, BTG1, KLF6, IRS2, RGCC, JUND, AHNAK, LMNA, TAGLN2. Mix of glucocorticoid/immune-regulatory genes (TSC22D3, BTG1, KLF6) and structural/cytoskeletal genes (LMNA, AHNAK, TAGLN2, CRIP1). Moderate coherence indicates mixed program. The GILZ-anchored immunoregulatory/quiescence theme (TSC22D3, BTG1, TSPYL2, JUND) is most distinctive, consistent with anti-inflammatory regulatory signaling.
Genes
AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, IRS2, JUND, KLF6, LETM2, LMNA, RBBP6, RGCC, RSF1, TAGLN2, TGIF2, TSC22D3, TSPYL2, UBTF, WSB1
Most correlated modules
- TCR early activation · correlation 0.73
- Integrated Stress Response · correlation 0.65
- Unfolded Protein Response · correlation 0.58
- DNA repair/replication · correlation 0.56
- NF-kB Feedback Response · correlation 0.56
- Heat Shock Response · correlation 0.51
- Pol II Transcription Regulation · correlation 0.50
- Immediate Early AP-1 · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.