Ceramide Lipid Metabolism
Gene co-expression module in Colorectal carcinoma
| Category | Glycolysis & Warburg effect |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub CERS6 (ceramide synthase 6) and ACSL5 (acyl-CoA synthetase long chain 5) are lipid metabolism enzymes; MLXIP (ChREBP, carbohydrate-responsive element binding protein) regulates lipid and glucose metabolism. FERMT1 (kindlin-1) mediates integrin-ECM signaling. ETS2, IRF2BP2 are transcriptional regulators. GOLIM4 is a Golgi membrane protein involved in lipid trafficking. ADD3 (adducin) links to cytoskeletal-membrane organization. SLC12A2 is an ion cotransporter. The module is dominated by a lipid/ceramide biosynthesis and metabolism program with regulatory elements, consistent with CRC metabolic reprogramming involving ceramide pathways and fatty acid activation.
Genes
Most correlated modules
- WNT Stem Cell · correlation 0.87
- RNA Splicing · correlation 0.84
- Post-transcriptional Regulation · correlation 0.73
- ER Protein Processing · correlation 0.72
- Ribosome Biogenesis · correlation 0.69
- Golgi-Nuclear Organization · correlation 0.69
- Epithelial Cell Junctions · correlation 0.66
- AP-1 IEG Activation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.