Golgi-Nuclear Organization
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
GOLGA4, GCC2, GOLGB1, AKAP9 are all large Golgi structural/tethering proteins that maintain Golgi architecture. SON (nuclear speckle scaffold), SRRM2 (SR matrix protein, nuclear speckles), PRRC2C (large RNA-binding), HNRNP-related BPTF (chromatin remodeling) and ANKRD11 are large nuclear organizational proteins. FOXP1, ZMYM2, ZKSCAN1 are transcription factors. The module is dominated by large structural proteins of the Golgi and nuclear compartments — a housekeeping/organelle integrity program. TTC3 is an E3 ligase involved in protein quality control. RRBP1 is an ER-Golgi membrane protein.
Genes
Most correlated modules
- Hypoxia Response · correlation 0.86
- Pre-mRNA Splicing · correlation 0.85
- RNA Splicing · correlation 0.83
- Epithelial Cell Junctions · correlation 0.71
- Ceramide Lipid Metabolism · correlation 0.69
- AP-1 IEG Activation · correlation 0.68
- WNT Stem Cell · correlation 0.61
- Colonocyte Differentiation · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.